​Myeloma Research Group

Our laboratory studies the molecular and cellular basis for the development of the bone marrow cancer, multiple myeloma. 

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Current Research Focus
​Current projects are focused on:
  • Identifying the genetic, transcriptional and epigenetic changes that trigger the progression from asymptomatic MGUS to myeloma
  • Determining why the bone marrow is a “hot-spot” for myeloma plasma cell metastasis
  • Identifying the mechanisms governing dissemination and relapse in multiple myeloma
  • Identifying the role played by the newly described tumour suppressor genes, GLIPR1 and SAMSN1, in multiple myeloma development
  • Determining the effects of myeloma plasma cells on mesenchymal stem cell (MSC) differentiation.
  • Assessing the effectiveness of targeting Class IIa Histone Deacetylases (HDAC) to treat myeloma and myeloma-associated bone disease
  • Identifying the role of the mTOR pathway in mesenchymal stem cell biology and bone formation.
  • Assessing the effectiveness of targeting skeletal mTORC1 as a novel approach to treat diet-induced insulin resistance
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+61 8 8128 4000 info@sahmri.com
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North Terrace Adelaide 5000 South Australia
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PO BOX 11060 Adelaide 5001 South Australia
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SAHMRI is located on the traditional lands of the Kaurna Nation.

The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.