Theme Member
Charlotte Downes

Contact

Phone: 08 81284344

Email: charlotte.downes@sahmri.com

LinkedIn: https://www.researchgate.net/profile/Charlotte_Downes

ResearchGate:https://www.linkedin.com/in/charlotte-downes//

Qualifications

Bachelor of Science (Advanced)

Honours of Bachelor of Science (First Class in Molecular and Cellular Biology)

Research Focus

My research investigates high-risk subtypes of acute lymphoblastic leukaemia (ALL), an aggressive blood cancer caused by the unregulated proliferation of white blood cells. Patients with fusion genes have been identified using whole genome sequencing and have been found to have an extremely poor prognosis. These fusion genes may be targetable by currently available tyrosine kinase inhibitors. My research aims to characterise a selectionof these fusion genes and elucidatemechanisms of resistance that may occur with treatment. I have characterised and generated resistance in an ALL cell line and am currently investigating their mechanisms of resistance. This work has the potential to inform combinational therapeutic strategies and guide future drug design to overcome or avert resistance in this high-risk patient cohort.

Awards

SAHMRI Summer Vacation Scholarship, 2016 and 2017

Faculty of Sciences Outstanding Academic Achievement Award, 2015 and 2016

Get in touch
+61 8 8128 4000 info@sahmri.com
You can't miss us!
North Terrace Adelaide 5000 South Australia
Postal Address
PO BOX 11060 Adelaide 5001 South Australia
Key Partners
SAHMRI is located on the traditional lands of the Kaurna Nation.

The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.