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Bachelor of Science (Biomedicine), University of Adelaide
Bachelor of Health Sciences (Honours, First Class), University of Adelaide
Localised solid tumour cells metastases to secondary site via a series of phenotypic and gene expression changes known as epithelial-to-mesenchymal transition (EMT), resulting in a motile and invasive phenotype. Although “metastasis” and “EMT” are not commonly used to describe the dissemination of haematological malignancies, recent studies from our laboratory showed that high-risk t(4;14) multiple myeloma (MM) patients express an EMT-like gene signature, suggesting a role for EMT in MM. My PhD project will determine major regulatory events leading to EMT-like programme in the dissemination of MM and will identify ideal therapeutic targets to control the spread of MM in high-risk patients with aggressive disease.
Cheong CM, Chow AW, Fitter S, Hewett DR, Martin SK, Williams SA, To LB, Zannettino AC, Vandyke K. Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo. Experimental Cell Research. 2015; 332(1):24-38
2013 PhD Scholarship, Adelaide Graduate Research Scholarship
2011 Summer Research Scholarship, Centre for Stem Cell Research