Theme Member
Dr Agnieszka (Agnes) Arthur

Contact Details

Phone: 81284695

Email: agnes.arthur@adelaide.edu.au

www.researchgate.net/profile/Agnieszka_Arthur

www.linkedin.com/pub/agnes-arthur/13/533/5b6

Qualifications: Bachelor of Science, Bachelor of Health Science (Hons), PhD, University of Adelaide

Biography/Research Focus

Skeletal disease such as osteoporosis is caused by the uncoupling of the bone remodelling process. This uncoupling causes the deterioration of the skeleton by a decrease in the production and thus function of bone forming cells and the increase of bone removing cells. This imbalance ultimately results in more brittle bones that have a higher incidence of fracture. Osteoporosis affects over 2 million Australians and costs the health system approximately $20 million/day. With such high prevalence and cost to the Australian health system, it is imperative that we identify novel therapies that limit side effects while treating osteoporosis effectively.

I am interested in understanding the communication between mesenchymal stem cells and their surrounding microenvironments. This communication is important during (1) bone remodelling, (2) bone disease and (3) repair following trauma. My research focuses on the function of a family of receptor tyrosine kinase molecules, the Eph receptors and ephrin ligands expressed by mesenchymal stem cells and within their microenvironment. My project aims to decipher the function of ephrinB1 on the skeletal stem cells and their derivatives during bone development, postnatal skeletal homeostasis/remodelling, during the onset of osteoporosis and following fracture repair. My project also aims to identify the signalling mechanisms by which ephrinB1/EphB molecules mediate their responses during these processes. This approach could potentially translate into alternative therapeutic treatments for patients with osteoporosis, to prevent fractures in high risk groups.

Publications

  1. Arthur A, Shi S and Gronthos S. (2015) Dental Pulp Stem Cells. Stem Cell Biology and Tissue Engineering in Dental Sciences. Editiors, A Vishwakarma, P Sharpe, S Shi, X Wang and M Ramalingam. Academic Press/Elsevier, Oxford UK. Part IV Chapter 21, p279-285.
  2. Nguyen TM, Arthur A, Hayball JD, Gronthos S. (2013) EphB and Ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells. Stem Cells Dev. 22(20):2751-64.
  3. Arthur A, Panagopoulos RA, Cooper L, Menicanin D, Parkinson IH, Codrington JD, Vandyke K, Zannettino AC, Koblar SA, Sims NA, Matsuo K, Gronthos S. (2013) EphB4 enhances the process of endochondral ossification and inhibits remodelling during bone fracture repair. J Bone Miner Res. 28(4):926-35.
  4. Arthur A, Zannettino A, Gronthos S. (2013) The multipotential of Mesenchymal / Stromal Stem Cells in Skeletal Tissue Repair. Stem Cells and Bone Tissue. Editors V.R. Preedy, R. Rajendram, V.B. Patel. CRC Press Taylor & Francis Group, Boca Raton, FL. Chapter 5, p82-102.
  5. Leong WK*, Henshall TL*, Arthur A*, Kremer KL*, Lewis MD, Helps SC, Field J, Hamilton-Bruce MA, Warming S, Manavis J, Vink R, Gronthos S, Koblar SA. (2012) Human adult dental pulp stem cells enhance post stroke functional recovery through non-neural replacement mechanisms. Stem Cells Transl Med. 1(3):177-87.
  6. Gronthos S, Arthur A, Bartold PM, Shi S. (2011) A method to isolate and culture expand human dental pulp stem cells. Methods Mol Biol. 698:107-21.
  7. Arthur A, Zannettino A, Panagopoulos R, Koblar SA, Sims NA, Stylianou C, Matsuo K, Gronthos S. (2011) EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation. Bone. 48(3):533-42.
  8. Psaltis PJ, Paton S, See F, Arthur A, Martin S, Itescu S, Worthley SG, Gronthos S, Zannettino AC. (2010) Enrichment for STRO-1 expression enhances the cardiovascular paracrine activity of human bone marrow-derived mesenchymal cell populations. J Cell Physiol. 223(2):530-40.

Awards/Funding

NH&MRC project grant (2015-2017)

Australian Dental Research Foundation (ARDF) project grant (2015)

Elizabeth Penfold Simpson Prize (From the Brain Foundation), for best neural publication (2014)

Mary Overton Research Fellowship (2013-2016)

International Osteoporosis Foundation (IOF), Young Investigator Award

Robinson Institute, Young Investigator Award (2009)

Travel award, Australian & New Zealand Bone & Mineral Society (2009)

Robinson Institute, Publication Award (2009)

Catholic Archdiocese of Sydney, Adult Stem Cell Research Award (2008)

Travel Award, Hanson Institute/IMVS, South Australia, Australia (2008)

Travel Grant from The Australian Stem Cell Centre, Monash University, Victoria (2005)

Travel Grant from Centre for the Molecular Genetics of Development, University of Adelaide (2005)

Travel Grant from Network in Genes and Environment in Development, University of Adelaide (2005)

Travel Grant from Faculty of Health Science, University of Adelaide (2005)

Faculty of Science Postgraduate Scholarship, University of Adelaide (2003).

The Queen Elizabeth Hospital Honours Scholarship Research Foundation, Queen Elizabeth Hospital, South Australia (2000)   

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