Theme Member
Dr Kate Vandyke

Contact Details

Phone: 08 8128 4694

Email: kate.vandyke@adelaide.edu.au

https://www.researchgate.net/profile/Kate_Vandyke

scholar.google.com.au/citations?hl=en&user=xyO5lYIAAAAJ

Qualifications:

BMedSc (Hons)

PhD

Biography/Research Focus

I am currently a Royal Adelaide Hospital Mary Overton Research Fellow in the Myeloma Research Laboratory, School of Medical Sciences, University of Adelaide, based at the SAHMRI, Cancer Theme. My PhD research, completed in 2010, centred on characterising the off-target effects of tyrosine kinase inhibitors, like imatinib, on bone metabolism and skeletal growth in chronic myeloid leukaemia. My current research interests involve elucidating the molecular and cellular mechanisms responsible for multiple myeloma disease progression, primarily focussing on investigating the mechanisms controlling myeloma dissemination. I am an affiliate lecturer in the School of Medical Sciences and the School of Medicine, University of Adelaide. I am an elected member of the Haematology Society of Australia and New Zealand and have served on the committee of the Australian Society of Medical Research SA Division since 2014.

Publications

  1. Cheong, C.M., Chow A.W.S., Fitter S., Hewett D.R., Martin S.K., Williams S.A., To L.B., Zannettino A.C.W., Vandyke K. Tetraspanin 7 (TSPAN7) expression is upregulated in multiple myeloma patients and inhibits myeloma tumour development in vivo. Experimental Cell Research (2015), 332(1):24-38.
  2. Gan Z.Y., Fitter S., Vandyke K., To L.B., Zannettino A.C.W., Martin S.K. The effect of the dual PI3K and mTOR inhibitor BEZ235 on tumour growth and osteolytic bone disease in multiple myeloma. European Journal of Haematology (2015), 39(3):380-387-38.
  3. Noll J.E., Hewett D.R., Williams S.A., Vandyke K., Kok C., To L.B., Zannettino A.C.W. SAMSN1 is a tumor suppressor gene in multiple myeloma. Neoplasia (2014), 16(7):572-585.
  4. Noll J.E., Vandyke K., Zannettino A.C.W. The role of the “cancer stem cell niche” in cancer initiation and progression. Adult Stem Cell Niches. InTech (2014), Chapter 9, 291-320. ISBN: 978-953-51-1718-6.
  5. Ahmed F., Dutta N.K., Zannettino A.C.W., Vandyke K., Choudhury N.R. Engineering interaction between bone marrow derived endothelial cells and electrospun surfaces for artificial vascular graft applications. Biomacromolecules (2014), 15(4):1276-1287.
  6. Vandyke K., Chow A.W., Williams S.A., To L.B., Zannettino A.C.W. Circulating N-cadherin levels are a negative prognostic indicator in patients with multiple myeloma. British Journal of Haematology (2013), 161(4):499-507.
  7. Vandyke K., Zannettino A.C.W. Side-effects of tyrosine kinase inhibitors on growth in paediatric patients. In ‘Imatinib: Chemical Structure, Pharmacology and Adverse Effects’. Nova Science Publishers (2013), Chapter 7, 115-128. ISBN: 978-1-62808-304-0.
  8. Arthur A., Panagopoulos R., Cooper L., Menicanin D., Parkinson I., Codrington J., Vandyke K., Zannettino A.C.W, Koblar S.A., Sims N.A., Matsuo K., Gronthos S. EphB4 enhances the process of endochondral ossification during bone fracture repair. Journal of Bone and Mineral Research (2012), 28(4):929-35.
  9. Vandyke K., Fitter S., Drew J., Fukumoto S., Schultz C.G., Sims N.A, Yeung D.T., Hughes T.P., Zannettino A.C.W. Prospective histomorphometric and DXA evaluation of bone remodelling in imatinib-treated CML patients: evidence for site-specific skeletal effects. Journal of Clinical Endocrinology and Metabolism (2013), 98(1):67-76.
  10. Fitter S., Vandyke K., Gronthos S., Zannettino A.C.W. Suppression of PDGF induced PI3K activity by imatinib promotes adipogenesis and adiponectin secretion. Journal of Molecular Endocrinology (2012), 48(3):229-40.
  11. Vandyke K., Fitter S., Zannettino A.C.W. The tyrosine kinase inhibitor dasatinib (SPRYCEL) inhibits chondrocyte activity and proliferation. Blood Cancer Journal (2011), 1(e2)doi:10.1038/bcj.2011.1.
  12. Fitter S., Vandyke K., Schultz C.G., White D., Hughes T.P., Zannettino A.C.W. Plasma adiponectin levels are markedly elevated in imatinib-treated chronic myeloid leukemia (CML) patients: a mechanism for improved insulin sensitivity in type 2 diabetic CML patients? Journal of Clinical Endocrinology and Metabolism (2010), 95(8):3763-7.
  13. Vandyke K., Dewar A.L., Diamond P., Fitter S., Schultz C.G., Sims N.A., Zannettino A.C.W. The tyrosine kinase inhibitor dasatinib dysregulates bone remodelling through inhibition of osteoclasts in vivo. Journal of Bone and Mineral Research (2010), 25(8):1759-70.
  14. Vandyke K., Dewar A.L., Fitter S., Hughes T.P., Zannettino A.C.W. Dysregulation of bone remodelling by imatinib mesylate. Blood (2010), 115(4):766-774.
  15. Vandyke K., Dewar A.L., Farrugia A.N., Fitter S., Menicanin D., To L.B., Hughes T.P., Zannettino A.C.W. Imatinib mesylate causes growth plate closure in vivo. Leukemia (2009), 23(11):2155-2159.
  16. Vandyke K., Dewar A.L., Farrugia A.N., Fitter S., To L.B., Hughes T.P., Zannettino A.C.W. Therapeutic concentrations of dasatinib inhibit in vitro osteoclastogenesis. Leukemia (2009), 23(5):994-997.

Awards/Funding

2014: Early Career Researcher Travel Award, CASS Foundation (Melbourne).

2014: Travel Award, Florey Medical Research Foundation (Adelaide).

2013: Mary Overton Early Career Research Fellowship, Royal Adelaide Hospital Research Foundation (Adelaide).

2013: Veronika Sacco Postdoctoral Clinical Cancer Research Fellowship, Florey Medical Research Foundation (Adelaide).

2012: PhD Thesis Research Excellence Award, Centre for Cancer Biology (Adelaide).

2011: MMRF Research Fellowship, Multiple Myeloma Research Foundation (Norwalk, Connecticut, USA).

2011: University Doctoral Research Medal, University of Adelaide (Adelaide).

2010: Dean’s Commendation, University of Adelaide (Adelaide).

2007: Australian Postgraduate Award Scholarship, University of Adelaide (Adelaide).

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SAHMRI is located on the traditional lands of the Kaurna Nation.

The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.