Phone: 08 8128 4387
PhD in Developmental Biology, University of Edinburgh
BSc in Biological Sciences with Honours in Physiology, University of Edinburgh
My role within the group is to develop and assess novel mouse models of colorectal cancer, using colonoscopy techniques that are very similar to patient surveillance in humans. In addition, I am developing an in vitro method of growing mouse and human stem cells from the colon with their associated connective tissue. This will allow us to further investigate these support cells in normal growth and cancer. Both systems will be directly therapeutically relevant, allowing us to assess preclinical targeting of molecular pathways relevant to colorectal cancer.
Peer-reviewed publications: Lannagan, T.R.M., Wilson, M.R., Denison, F., Norman, J.E., Catalano, R.D., Jabbour, H.N. (2013) Prokineticin 1 induces a pro-inflammatory response in murine fetal membranes but does not induce preterm delivery. Reproduction 146 (6):581-591.
Filis, P., Lannagan, T., Thomson, A., Murray, A.A., Kind, P.C. & Spears, N. (2009) Phospholipase C-beta 1 signalling affects reproductive behaviour, ovulation and implantation. Endocrinology 150: 3259-66. Contribution percentage: 30%
Review article: Catalano, R.D., Lannagan, T.R., Gorowiec, M., Denison, F.C., Norman, J.E., Jabbour, H.N. (2010) Prokineticins: novel mediators of inflammatory and contractile pathways at parturition? Mol Hum Reprod 16 (5): 311-9. Contribution percentage: 35%
Selected Conference (Oral and Poster) Presentations (all peer-reviewed abstracts):
2015 Oral presentation
Vrbanac L, Lannagan T, Yang M, Wang T, Woods S, Mukherjee S, Wang TC, Worthley DL. (2015) Gremlin 1 defines a connective tissue stem cell in the gastrointestinal tract, bone and tumor microenvironment. Gastroenterological Society of Australia. Hepatology and Gastrointestinal Research Workshop. NSW, Australia.
2014 Oral presentation
Lannagan, T.R.M., Lockett, T., Ernst, M. & Cosgrove, L.J. (2014) Mutagen-induced DNA damage and tumour burden in mouse colon is increased in response to prior chronic inflammation. Australian Society for Medical Research, SA Annual Scientific Meeting. Adelaide, Australia.
2012 Poster presentation
Lannagan, T.R.M., Ernst, M. & Cosgrove, L.J. (2012) Mutagen-induced aberrant crypt foci formation in mouse colon is increased in response to prior inflammation. The 6th Australian Health and Medical Research Congress. Adelaide, Australia.
2011 Oral presentation
Lannagan, T.R.M., Wilson, M.R., Battersby, S., Denison, F.C., Norman, J.E., Bennett, P.R., Catalano, R.D. & Jabbour, H.N. (2011) The Mouse and the Membranes: a Role for Prokineticins in Infection- Induced Preterm Labor. Annual Meeting of the Society for Gynaecologic Investigation. Miami, USA.
2010 Oral presentation
Lannagan, T.R.M., Battersby, S., Rinaldi, S.F., Denison, F.C, Norman, J.E., Catalano, R.D. & Jabbour, H.N. (2010) A putative role for prokineticins in infection-induced preterm labour – an amnion perspective. 60th Annual Meeting of the Society for Reproduction and Fertility. Nottingham, UK.
At the 2014 ASMR South Australian Scientific Meeting I was awarded the Best Oral Presentation by an Early Career Researcher.
I was awarded a prestigious Office of the Chief Executive Postdoctoral Fellowship at CSIRO in Australia (2011- 2014).
I won a highly competitive Career Development Fellowship (2009-2011) from the UK Medical Research Council.
My PhD studies were funded by a national, competitive scholarship supported by the Biotechnology and Biological Sciences Research Council.
I have also obtained ten travel grants from a variety of funding bodies.