Theme Member
Thao Nguyen

Qualification:

2003: Bachelor of Medical and Pharmaceutical Biotechnology, University of South Australia

Biography/Research Focus

Thao Nguyen’s research focuses in understanding the fundamental mechanisms involved in controlling how bone marrow derived mesenchymal stem cells (BMSC) support the process of blood cell formation and modulate immune cell responses. Of major interests are the role of Eph receptor tyrosine kinases and ephrin ligands in these processes. Her PhD study showed that EphB4, expressed by BMSC, enhances haematopoietic reconstitution following bone marrow transplantation. In addition, EphB2 and ephrin-B2, expressed by ex-vivo expanded human BMSC, mediate the suppression of activated human T-cells by interacting with their cognate binding partners expressed on the T-cells. Her current research investigates the role of Eph/ephrin interactions in BMSC-mediated bone regeneration, support of haematopoiesis and immune cell regulation.

Publications

  1. Nguyen TM, Arthur A, Hayball JD, Gronthos S. EphB and ephrin-B interactions mediate human mesenchymal stem cell suppression of activated T-cells. Stem Cells and Dev, 2013, 22 (20): 2751-2764
  2. Sasseville M, Ritter LJ, Nguyen TM, Liu F, Mottershead DG, Russell DJ, Gilchrist R. Growth differentiation factor 9 signaling requires mitogen-activated protein kinase 3/1 activity in mouse granulosa and cumulus cells. Journal of Cell Sci, 2010, 123: 3166-3176

Awards/Funding

2014:Best Student Oral Presentation Award at the Australasian Society for Stem Cell Research (ASSCR) and Cellular Therapy meeting, Lorne,Victoria, Australia.

2014: Travel grantawarded by The National Stem Cell Foundation of Australia (NSCFA) to attend the 7th ASSCR Annual Meeting, Lorne, Victoria, Australia.

2013: Travel grant awarded by the International Society for Hematology and Stem Cells (ISEH) to attend the 42nd ISEH annual scientific meeting, Vienna, Austria.

2013: Travel grant awarded bythe NSCFA to attend the 6th ASSCR Annual Meeting, Brisbane, Australia

2013: Student Poster Award – 2nd Place, awarded at the Australian Society for Medical Research Annual Scientific Meeting, Adelaide chapter, Adelaide, Australia.

2011 – 2013:University of South Australia Post-Graduate Award

1999 – 2002:Equity HECS Exemption Scholarship awarded by the University of South Australia.

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SAHMRI is located on the traditional lands of the Kaurna Nation.

The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.