Theme Member
Nadia El Khawanky

Contact Details

Email: nadia.el-khawanky@student.adelaide.edu.au

Qualifications:

B.Sc (Biomedical Science)

Biography/Research Focus

The hematopoietic development program requires unique microenvironments that modulate the differentiation and homeostasis of specific blood cell subsets. Research has characterized Osteoblasts as being an essential stromal cell line imperative in early B-cell development and differentiation, showing their ability to support B cell development by secreting CXCL12 and IL-7 soluble factors. Past studies from the Myeloma Research Laboratory have investigated the metabolic mTORC1 protein complex and its role in Osteogenesis, showing that conditional deletion of its Raptor adaptor protein component alters the integrity and function of Osteoblasts in skeletal development. Moreover, hematopoietic assessment showed abnormalities in early B-cell development with a significant elevation in pre-pro B cell numbers and a decrease in pro-B cells. Preliminary findings indicate an important mechanistic role of Osteoblast specific mTORC1 in B lymphopoiesis, however the mechanisms of how OB-mTORC1 supports B lymphopoiesis and whether this is a direct or indirect mechanism is currently undefined and will be investigated in my honours research. 

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Key Partners
SAHMRI is located on the traditional lands of the Kaurna Nation.

The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.