Multiple myeloma (MM) is an incurable bone marrow (BM) malignancy caused by the uncontrolled proliferation of neoplastic antibody-secreting plasma cells (PC). MM is almost always preceded by an asymptomatic disease stage, known as monoclonal gammopathy of undetermined significance (MGUS). The genetic mutations present in MGUS and MM vary significantly between patients and the key genetic drivers of disease progression remain poorly understood. My PhD project aims to investigate a few key genes, the loss of which may contribute to the development of MM. This may lead to the identification of new molecular markers of disease risk and novel therapeutic targets in MM.