Theme Leader

Professor Timothy P. Hughes, MD, FRACP, FRCPA, MBBS, FAAHMS

Professor Timothy Hughes is the Cancer Theme Leader at SAHMRI, Beat Cancer Professor, University of Adelaide and Consultant Haematologist in the Division of Haematology in the Royal Adelaide Hospital. He is also Chair of the International Chronic Myeloid Leukemia Foundation (iCMLf); Fellow of the Australian Academy of Health and Medical Sciences (AAHMS).

Professor Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays that influence the way CML patients are managed world-wide. He has published over 280 papers that have been cited over 40,000 times.

10 significant publications

H Factor 83 Citations 42104

1.Hughes TP, Kaeda J, Branford S, Rudzki Z, Hochhaus A, Henslee ML, Gathmann I, Bolton AE, van Hoomissen IC, Goldman JM and Radich J. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed patients with chronic myeloid leukemia. 2003 New England Journal of Medicine 349:1423-32 CIT 1314 This landmark paper was the first to define MMR and to demonstrate that achievement of MMR was predictive of a very low risk of disease progression.

2.Michor F, Hughes TP, Iwasa Y, Branford S, Shah N, Sawyers C, Nowak A. Dynamics of chronic myeloid leukaemia. 2005 Nature (A*) 435(7046):1267-70 CIT 744 The first mathematical model of a human cancer predicted that leukaemic stem cells may not be reduced by imatinib. The primary data used for this mathematical model was produced in our lab.

3.Hughes TP, Deininger MW, Hochhaus A, Branford S, Radich JP, Kaeda J, Baccarani M, Cortes J, Cross NC, Druker BJ, Gabert J, Grimwade JH, Longtine J, Martinelli G, Saglio G, Soverini S, Stock W, Goldman J. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors – Review and recommendations for ‘harmonizing’ current methodology for detecting BCR-ABL transcripts and kinase domain mutations and for expressing results. 2006 Blood (A*) 108(1) 28-37 CIT 1123. I led the global move to standardise PCR measurement of MRD in CML.

4.Druker B, Guilhot F, O’Brien S, Gathman I, Kantasrjian H, Gattermann N, Deininger M, Silver R, Goldman J, Stone R, Cervantes F, Hochhaus A, Powell B, Gabrilove J, Rousselot P, Reiffers J, Cornelissen J, Hughes TP, Agis H, Fischer T, Verhoef G, Shepherd J, Saglio G, Gratwohl A, Nielsen J, Radich J, Simonsson B, Taylor K, Baccarani M, So C, Letvak L, Larson R. Five-year follow up of patients receiving Imatinib for chronic myeloid leukaemia. 2006 New England Journal of Medicine (A*) 355 (2408-17) CIT 3258

5.Hughes TP, Branford S White DL, Reynolds J, Koelmeyer, Seymour JF, Taylor K, Arthur C, Schwarer A, Morton J, Cooney J, Leahy MF, Rowling P, Catalano J, Hertzberg M, Filshie R, Mills AK, Fay K, Durrant S, Januszewicz, Joske D, Underhill C, Dunkley S, Lynch K, Grigg A on behalf of the Australasian Leukaemia and Lymphoma Group. Impact of early dose intensity on cytogenetic and molecular responses in chronic phase CML patients receiving 600 mg/day. 2008 Blood (A*) 112(10) 3965-3973 CIT 156

6.Hughes TP, Saglio G, Branford S, Soverini S, Kim D-W, Muller MC, Martinelli G, Cortes J, Beppu L, Gottardi E, Kim D, Erben P, Shou Y, Haque A, Gallagher N, Radich J, Hochhaus A. Impact of baseline BCR-ABL mutations on response to Nilotinib in patients with chronic myeloid leukaemia in chronic phase. 2009 Journal of Clinical Oncology (A*) 27(25) 4204-10 CIT 302 JCO is the premium oncology journal. I led the international panel that reviewed the mutation data from this trial to identify a limited number of mutations as resistant to nilotinib.

7.Cortes JE, Kim DW, Pinilla-Ibarz J, le Coutre P, Paquette R, Chuah C, Nicolini FE, Apperley JF, Khoury HJ, Talpaz M, DiPersio J, DeAngelo DJ, Abruzzese E, Rea D, Baccarani M, Müller MC, Gambacorti-Passerini C, Wong S, Lustgarten S, Rivera VM, Clackson T, Turner CD, Haluska FG, Guilhot F, Deininger MW, Hochhaus A, Hughes TP, Goldman JM, Shah NP, Kantarjian H; PACE Investigators. A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemias. New England Journal Medicine. 2013 369(19)1783-1796 CIT 555

8. Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik A, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan Q, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross D, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen N, Sellers WR. The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL. Nature. 30 March 2017 543 (7647) 733-737 CIT 32

9. Hochhaus A, Larson RA, Guilhot F, Radich J, Branford S, Hughes TP, Baccarani M, Deininger MW, Cervantes F, Fujihara S, Ortmann C, Menssen H, Kantarjian H, O’Brien S, Druker B. IRIS Final Analysis: Long-Term outcomes with Imatinib treatment for CML. New England Journal Medicine. March 2017 376 (10) 917-927 CIT 84

10.Mahon FX, Boquimpani C, Kim DW, Benyamini N, Clementino NCD, Shuvaev V, Ailawadhi S, Lipton JH, Turkina AG, Paz R, Moiraghi B, Nicolini FE, Dengler J, Sacha T, Takahashi N, Fellague-Chebra R, Acharya S, Wong S, Jin Y, Hughes TP. Treatment-Free remission after second-line nilotinib treatment in patients with chronic myeloid leukemia in chronic phase: results from a single-group, Phase 2, open-label study. Annals of Internal Medicine Feb 2018

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