Associate Professor Bev Mühlhäusler

Contact details:

08 8313 0848

beverly.muhlhausler@adelaide.edu.au

Qualifications:

BSc (Hons), PhD

Brief biography:

A/ProfBev Mühlhäusler is Head of the Obesity and Metabolic Health Division and Deputy Director of the FOODplus Research Centre, a joint venture between the University of Adelaide and SAHMRI.

Bev is a SAHMRI affiliate who actively collaborates with several members of the HMBC theme. Bev’s primary research interest is the perinatal origins of obesity and poor metabolic health, and she has a particular interest in determining the mechanisms through which maternal obesity and poor quality ‘Western-style’ diets act to predispose the offspring to obesity and type 2 diabetes. More recently, Bev has developed a keen interest in identifying potential nutritional interventions for breaking this intergenerational cycle of obesity and poor metabolic health, with a particular focus on omega-3 long chain fatty acids. She is currently leading both pre-clinical and clinical studies in this area.

Bev holds a Level 2 Career Development Fellowship from the National Health and Medical Research Council of Australia and has published over 80 peer-reviewed manuscripts in the field of perinatal nutrition and developmental programming since 2002.

Selected Awards/Honours:

Career Development Award Level 2, National Health and Medical Research Council (NHMRC), (2015-2018).

Waite Research Institute Research Leaders Program (2012-13)

Early Career Researcher Award, Faculty of Sciences University of Adelaide (2011)

Junior Faculty Award, Developmental Origins of Health and Disease Society (2011)

New Investigator Award, International Society for the Study of Fatty Acids and Lipids (2010,2012)

Distinguished Presentation Award, International Congress of Nutrition (2009)

President’s Presenter Award, US Society for Gynecologic Investigation (2007)

Invited Participant – 2020 Summit (Health Future Stream) (2008)

South Australian Science Excellence Awards Team Leader – The SA Committee of the Australian Society for Medical Research (2007)

School of Molecular and Biomedical Science Publication Award, The University of Adelaide (2005)

New Investigator Award from the Perinatal Society of Australia and New Zealand (2007)

NHMRC Early Career Researcher Award, The Australian Academy of Science (2007)

South Australian Young Tall Poppy Science Award (2007)

Selected publications – past five years:

1. Vithayathil MA, Gugusheff JR, Gibson RA, Ong ZY, Muhlhausler BS. Effect of a maternal cafeteria diet on the fatty acid composition of milk and offspring red blood cells. Prostaglandins Leukot Essent Fatty Acids. 2016 Jun;109:58-65.

2. Muhlhausler BS, Yelland LN, McDermott R, Tapsell L, McPhee A, Gibson RA, Makrides M. DHA supplementation during pregnancy does not reduce BMI or body fat mass in children: follow-up of the DHA to Optimize Mother Infant Outcome randomized controlled trial. Am J Clin Nutr. 2016 Jun;103(6):1489-96.

3. Hodyl NA, Muhlhausler B. Novel insights, challenges and practical implications of DOHaD-omics research. Med J Aust. 2016 Feb 15;204(3):108-10.

4. Prescott SL, Allen K, Armstrong K, Collins C, Dickinson H, Gardiner K, Jacka F, Jasoni C, Moore T, Moritz KM, Muhlhausler B, Siero W, Sim K, Nanan R, Saffery R, Singh G, Vickers MH, Craig JM The establishment of DOHaD working groups in Australia and New Zealand. J Dev Orig Health Dis. 2016 Apr 27:1-7.

5. Wood KE, Mantzioris E, Gibson RA, Ramsden CE, Muhlhausler BS The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: A systematic review and commentary. Prostaglandins Leukot Essent Fatty Acids. 2015 95:47-55.

6. Gugusheff JR, Ong ZY, Muhlhausler BS. The early origins of food preferences: targeting the critical windows of development. FASEB J. 2015 29:365-373.

7. Toop CR, Muhlhausler BS , O'Dea K, Gentili S. Consumption of sucrose, but not high fructose corn syrup, leads to increased adiposity and dyslipidaemia in the pregnant and lactating rat. J Dev Orig Health Dis. 2015 6:38-46.

8. Muhlhausler BS, Vithayathil MA Impact of Maternal Obesity on Offspring Adipose Tissue: Lessons for the Clinic. Exp Rev Endocrinol. 2014 9: 615-627

9. Muhlhausler BS, Gugusheff JR, Ong ZY, Vithayathil MA Pregnancy, obesity and insulin resistance: maternal overnutrition and the target windows of fetal development Horm Mol Biol Clin Investig. 2013 15: 25-36

10. Muhlhausler BS, Ailhaud G Omega-6 Polyunsaturated Fatty Acids (PUFA) and the Early Origins of Obesity Curr Opin Endocrinol Diabetes Obes 2013 20:56-61

11. Muhlhausler BS, Bloomfield FH, Gillman MW Whole animal experiments should be more like randomized controlled trials PLoS Biol 2013 Feb;11:e1001481

12. Ong ZY, Gugusheff JR, Muhlhausler BS The programming of food preferences: pathways and mechanisms J Dev Origins Health Dis 2012 3:299-308.

13. Liu G, Muhlhausler BS, Gibson RA.A method for long term stabilisation of long chain polyunsaturated fatty acids in dried blood spots and its clinical application. Prostaglandins Leukot Essent Fatty Acids. 2014 91:251-60

14. Huynh D, Zhou SJ, Gibson R, Palmer L, Muhlhausler BS. Validation of an optimized method for the determination of iodine in human breast milk by inductively coupled plasma mass spectrometry (ICPMS) after tetramethylammonium hydroxide extraction. J Trace Elem Med Biol. 2015 29:75-82.

15. Molloy P, Samaras K, Muhlhausler BS, McMillen IC, The Epigenome and Human Obesity Med J Aust 2013 4:182.

16. Muhlhausler BS , Gugusheff JR, Ong ZY, Vithayathil MA. Nutritional approaches to breaking the intergenerational cycle of obesity. Can J Physiol Pharmacol. 2013 91:421-8

17. Muhlhausler BS , Gibson RA, Yelland LN, Makrides M. Heterogeneity in cord blood DHA concentration: towards an explanation. Prostaglandins Leukot Essent Fatty Acids. 2014 91:135-40.

18. Gugusheff JR, Ong ZY, Muhlhausler BS, Naloxone treatment alters gene expression in the mesolimbic reward system of 'junk food' exposed offspring in a sex-specific manner but does not affect food preferences in adulthood Physiol Behav 2014;133:14-21

19. Wood KE, Lau A, Mantzioris E, Gibson RA, Ramsden C, Muhlhausler BS . A low omega-6 polyunsaturated fatty acid (n-6 PUFA) diet increases omega-3 (n-3) long chain PUFA status in plasma phospholipids in humans Prostaglandins Leukot Essent Fatty Acids 2014 90:133-8.

20. Van Dijk S, Molloy P, Varinli H, Morrison JL, Muhlhausler BS Epigenetics and Human Obesity Int J Obes (Lond) 2015 39:85-97

21. Lie S, Hui M, McMillen IC, Muhlhausler BS, Posterino G, Dunn S, Wang K, Botting K, Morrison JL Exposure to rosiglitazone,a PPARγ agonist, in late gestation reduces the abundance of factors regulating cardiac metabolism and cardiomyocyte size in sheep Am J PhysiolRegul Integr Compar Physiol. 2014 306: R429-37.

22. Rattanatray L, Muhlhausler BS, Nicholas LM, Morrison JL, McMillen IC, Impact of Maternal Overnutrition on Gluconeogenic Factors and Methylation of the Phosphoenolpyruate Carboxykinase Promoter in the Fetal and Postnatal Liver Pediat Res 2014 75:14-21

23. Gray B, Muhlhausler BS, Davies PS, Vitetta L, Liver enzymes but not free fatty acid levels predict markers of insulin sensitivity in overweight and obese, nondiabetic adults. Nutr Res 2013 33:781-8

24. Ong ZY, Muhlhausler BS Consuming a low-fat diet from weaning to adulthood reverses the programming of food preferences in male, but not in female, offspring of 'junk food'-fed rat dams. Acta Physiol (Oxf). 2014 210:127-41.

25. Gugusheff JR, Vithayathil M, Ong ZY, Muhlhausler BS, The effects of prenatal exposure to a 'junk food' diet on offspring food preferences and fat deposition can be mitigated by improved nutrition during lactation, J Dev Origins Health Dis. 2013 4:348-357

26. Ong ZY, Wanasuria AF, Lin MZ, Hiscock J, Muhlhausler BS Chronic intake of a cafeteria diet and subsequent abstinence. Sex-specific effects on gene expression in the mesolimbic reward system. Appetite. 2013 65:189-99.

27. Gugusheff JR, Ong ZY, Muhlhausler BS. A maternal "junk-food" diet reduces sensitivity to the opioid antagonist naloxone in offspring postweaning. FASEB J 2013 27:1275-84

28. Wood KE, Mantzioris E, Gibson RA, Muhlhausler BS Incorporating macadamia oil and butter to reduce dietary omega-6 polyunsaturated fatty acid (PUFA) intake J Nutr Diet 2013 70:94–100

Book chapters:

29. Muhlhausler BS, Gugusheff JR Prenatal programming of the mesolimbic reward pathway and food preferences in Prenatal and Postnatal Determinants of Development (2015) [Accepted Nov 2014]

30. Muhlhausler BS, Toop C, Gentili S Nutritional Models of Type 2 Diabetes’ in Methods in Molecular Biology (2015) [Accepted Jan 2015]

31. Muhlhausler BS 2011 Roles of Pancreatic Cell Functions, Liver, Skeletal Muscle and Adipose Tissues in Diabetes and Metabolic Syndrome In Nutritional and Therapeutic Interventions of Tissues in Diabetes and Metabolic D Bagchi & S Nair (Eds), Elsevier

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