The Mind and Brain theme focuses on the continuum of mental health from major depression to wellbeing and resilience. We are interested in depression, mechanisms of antidepressant response, outcomes of antidepressant treatments, including the interface with metabolic syndrome and obesity. On the other end of the spectrum, we also want to promote wellbeing and resilience. As a new direction, addressing a consumer-driven initiative, we have developed an exciting and conceptually novel program on molecular imaging of the spinal cord that not only advances diagnosis and prognosis of spinal cord injuries, but also provides an imaging infrastructure to our program. That project exemplifies consumer-driven research and is called Project Discovery.