Our group focuses on studying the signalling pathways that regulate protein synthesis in mammalian cells, and their roles in normal physiology and in disease. We are especially interested in the mammalian target of rapamycin complex 1 (mTORC1) pathway and its downstream targets, particularly eukaryotic elongation factor 2 kinase, eEF2K. Another major area of interest concerns the protein kinases termed Mnks, Mnk1 and Mnk2, and their roles in controlling protein synthesis and gene expression. We study the roles of these pathways in a range of disorders, including cancers, neurological and cardiovascular diseases, and in obesity and type 2 diabetes.
Our research interests currently include:
The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.