Cell Signalling and Gene Regulation Group

Our group focuses on studying the signalling pathways that regulate protein synthesis in mammalian cells, and their roles in normal physiology and in disease. We are especially interested in the mammalian target of rapamycin complex 1 (mTORC1) pathway and its downstream targets, particularly eukaryotic elongation factor 2 kinase, eEF2K. Another major area of interest concerns the protein kinases termed Mnks, Mnk1 and Mnk2, and their roles in controlling protein synthesis and gene expression. We study the roles of these pathways in a range of disorders, including cancers, neurological and cardiovascular diseases, and in obesity and type 2 diabetes.

People within this group
Current Research Focus

Our research interests currently include:

  • the role of eEF2K in cancer cells, where it serves a cytoprotective role;
  • The role of eEF2K in neuronal cells, where it regulates protein synthe-sis, plays an important role in learning & memory, and is involved in depression
  • The discovery of novel eEF2K inhibitors, which may be useful in anti-cancer therapy
  • The role of the Mnks in controlling the synthesis of specific proteins in cancer cells and in neurons
  • The molecular events that underlie responses to high fat feeding and the development of insulin resistance and type 2 diabetes
  • The role of the nutrient-regulated mTORC1 pathway in responses to diet and other nutritional interventions 
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+61 8 8128 4000 info@sahmri.com
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North Terrace Adelaide 5000 South Australia
Postal Address
PO BOX 11060 Adelaide 5001 South Australia
Key Partners
SAHMRI is located on the traditional lands of the Kaurna Nation.

The SAHMRI community acknowledges and respects the traditional owners, the family clans who are the Kaurna Nation from the Adelaide Plains region of South Australia. We acknowledge the clans of the Kaurna Nation and the sacred knowledge they hold for their country. We pay our respects to the Kaurna Nation, their ancestors and the descendants of these living family clans today.